Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting

Rozemarijn W. D. Kleinendorst, Guido Barzaghi, Mike L. Smith, Judith B. Zaugg, Arnaud R. Krebs

Published: 2021-11-11 DOI: 10.1038/s41596-021-00630-1

single-molecule footprinting

transcription factor binding

methyltransferase

bisulfite sequencing

gene expression control

AI 解读

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Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting

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Precise control of gene expression requires the coordinated action of multiple factors at cis-regulatory elements. We recently developed single-molecule footprinting to simultaneously resolve the occupancy of multiple proteins including transcription fact
Introduction
Materials
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Troubleshooting
Timing
Anticipated results
References
ACKNOWLEDGMENTS
ACKNOWLEDGMENTS

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Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting

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